Synthetic retinoid Am80 inhibits interaction of KLF5 with RARα through inducing KLF5 dephosphorylation mediated by the PI3K/Akt signaling in vascular smooth muscle cells
作者： Xin-hua Zhang , Bin Zheng , Mei Han , Sui-bing Miao , Jin-kun Wen
DOI: 10.1016/J.FEBSLET.2009.03.016
关键词:
摘要: Abstract Kruppel-like factor 5 (KLF5) is known to physically interact with retinoic acid receptor-α (RARα). Here, we show that Am80 inhibited the interaction between KLF5 and RARα this inhibitory effect was accompanied by dephosphorylation of in VSMCs. Treating VSMCs LY294002, PI3K/Akt inhibitor, abrogated Am80-induced reversed suppression RARα, whereas treating vascular smooth muscle cells (VSMCs) SB203580, p38 kinase attenuated RARα. Constitutively active MKK6b infection prevented induced Am80. In conclusion, induces activating signaling, inhibits phosphorylation blocking subsequently leading Structured summary MINT- 7013243 : Klf5 (uniprotkb: Q66HP1 ) interacts (MI: 0218 RAR alpha Q9QWJ1 anti bait coimmunoprecipitation 0006
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