Quinazoline derivatives as inhibitors of P-38 α

摘要: The invention describes compounds of the formula and pharmaceutically acceptable salts thereof wherein each R 2 is independently a noninterfering substituent; m an integer 0-4; Z CH or N; 1 H, alkyl (1-6C) arylalkyl optionally substituted on aryl group with 1-3 substituents selected from (1-6C), halo, OR, NR , SR, —OOCR, —NROCR, RCO, —COOR, —CONR —SO CN, CF 3 NO H lower (1-4C); n 0, 2; Ar phenyl, pyridyl, indolyl, pyrimidyl, consisting SO branched cyclic (5-7C) phenyl 1-2 which are (1-4C) useful as antiinflammatories in treating cardiac disorders.