Superoxide Dismutase (SOD) Genes and Aging in Drosophila
作者： John Tower
DOI: 10.1007/978-3-319-18326-8_3
关键词:
摘要: Since their discovery by McCord and Fridovich the superoxide dismutase (SOD) enzymes have been of particular interest to field aging. The Drosophila SOD genes are required for normal oxidative stress resistance life span, targets investigation mechanisms ability affect span is dependent upon genetic background, including sex animal, as well dietary environment. There increasing understanding role SODs in signaling pathways that modulate Cu/ZnSOD important linking diet MnSOD can activate mitochondrial unfolded protein response increase span. also survival models human disease. conservation functions combined with availability powerful transgenic technologies promises keep at forefront research on aging SOD.
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Yuh-Ru Lin, Keetae Kim, Yanfei Yang, Andreas Ivessa, Junichi Sadoshima, Yongkyu Park, Regulation of longevity by regulator of G-protein signaling protein, Loco Aging Cell. ,vol. 10, pp. 438- 447 ,(2011) , 10.1111/J.1474-9726.2011.00678.X
Andrew J Elia, Tony L Parkes, Kim Kirby, Peter St, George-HyslopGabrielle L Boulianne, John P Phillips, Arthur J Hilliker, Expression of human FALS SOD in motorneurons of Drosophila. Free Radical Biology and Medicine. ,vol. 26, pp. 1332- 1338 ,(1999) , 10.1016/S0891-5849(98)00333-5
Lori A. Sturtz, Roland Lill, Laran T. Jensen, Valeria Cizewski Culotta, Kerstin Diekert, A fraction of yeast Cu,Zn-superoxide dismutase and its metallochaperone, CCS, localize to the intermembrane space of mitochondria. A physiological role for SOD1 in guarding against mitochondrial oxidative damage. Journal of Biological Chemistry. ,vol. 276, pp. 38084- 38089 ,(2001) , 10.1074/JBC.M105296200
Richard A. Weisiger, Irwin Fridovich, Mitochondrial Superoxide Dismutase Journal of Biological Chemistry. ,vol. 248, pp. 4793- 4796 ,(1973) , 10.1016/S0021-9258(19)43735-6
Jingtao Sun, John Tower, FLP Recombinase-Mediated Induction of Cu/Zn-Superoxide Dismutase Transgene Expression Can Extend the Life Span of Adult Drosophila melanogaster Flies Molecular and Cellular Biology. ,vol. 19, pp. 216- 228 ,(1999) , 10.1128/MCB.19.1.216
Jake Jacobson, Adrian J. Lambert, Manuel Portero-Otín, Reinald Pamplona, Tapiwanashe Magwere, Satomi Miwa, Yasmine Driege, Martin D. Brand, Linda Partridge, Biomarkers of aging in Drosophila Aging Cell. ,vol. 9, pp. 466- 477 ,(2010) , 10.1111/J.1474-9726.2010.00573.X
Yoko Honda, Shuji Honda, The daf-2 gene network for longevity regulates oxidative stress resistance and Mn-superoxide dismutase gene expression in Caenorhabditis elegans The FASEB Journal. ,vol. 13, pp. 1385- 1393 ,(1999) , 10.1096/FASEBJ.13.11.1385
Xiaoping Sun, Toshimitsu Komatsu, Jinhwan Lim, Mara Laslo, Jason Yolitz, Cecilia Wang, Luc Poirier, Thomas Alberico, Sige Zou, Nutrient‐dependent requirement for SOD1 in lifespan extension by protein restriction in Drosophila melanogaster Aging Cell. ,vol. 11, pp. 783- 793 ,(2012) , 10.1111/J.1474-9726.2012.00842.X
Atanu Duttaroy, Amy Belton, Anirban Paul, Mukta Kundu, A Sod2 null mutation confers severely reduced adult life span in Drosophila. Genetics. ,vol. 165, pp. 2295- 2299 ,(2003) , 10.1093/GENETICS/165.4.2295
Joe M. McCord, Irwin Fridovich, Superoxide Dismutase AN ENZYMIC FUNCTION FOR ERYTHROCUPREIN (HEMOCUPREIN) Journal of Biological Chemistry. ,vol. 244, pp. 6049- 6055 ,(1969) , 10.1016/S0021-9258(18)63504-5