Pattern recognition receptors in fungal immunity.

摘要: Over the last decade, invasive fungal infections have emerged as a growing threat to human health worldwide and novel treatment strategies are urgently needed. In this context, investigations into host-pathogen interactions represent an important promising field of research. Antigen presenting cells such macrophages dendritic strategically located at frontline defence against potential invaders. Importantly, these express germline encoded pattern recognition receptors (PRRs), which sense conserved entities from pathogens orchestrate innate immune responses. Herein, we review latest findings regarding biology functions different classes PRRs involved in pathogenic recognition. We also discuss recent literature on PRR collaboration/crosstalk mechanisms inhibiting/regulating signalling. Finally, how accumulated knowledge biology, especially Dectin-1, has been used for design new immunotherapies infections.