Effects of substance P and neurotensin on growth hormone and thyrotropin release and
作者： E. Vijayan , S.M. McCann
DOI: 10.1016/0024-3205(80)90344-6
关键词:
摘要: Abstract Conscious ovariectomized (OVX) rats bearing a cannula implanted in the third ventricle were injected with 2 μl of 0.9% NaCl containing varying doses substance P (SP) or neurotensin (NT) and plasma GH TSH levels measured by RIA jugular blood samples drawn through an indwelling silastic catheter. Control injections physiologic saline iv into did not modify hormone levels. Intraventricular injection SP NT at either 0.5 μg elevated concentrations within 5 min they remained for 60 min. Third ventricular similar had no effect on TSH. An intermediate dose 1 given but Incubation hemipituitaries from OVX alter release medium was enhanced 100 more ng/ml medium. It is suggested that acts centrally to stimulate growth hormone-releasing factor (GRF) inhibit somatostatin thereby enhance directly pituitary release.
elsevier.com
sci-hub.se 参考文章(15)
Michael M. Chang, Susan E. Leeman, Isolation of a sialogogic peptide from bovine hypothalamic tissue and its characterization as substance P Journal of Biological Chemistry. ,vol. 245, pp. 4784- 4790 ,(1970) , 10.1016/S0021-9258(18)62860-1
Robert Carraway, Susan E. Leeman, The Isolation of a New Hypotensive Peptide, Neurotensin, from Bovine Hypothalami Journal of Biological Chemistry. ,vol. 248, pp. 6854- 6861 ,(1973) , 10.1016/S0021-9258(19)43429-7
E. Vijayan, W.K. Samson, S.M. McCann, In vivo and in vitro effects of cholecystokinin on gonadotropin, prolactin, growth hormone and thyrotropin release in the rat. Brain Research. ,vol. 172, pp. 295- 302 ,(1979) , 10.1016/0006-8993(79)90539-0
Edathil Vijayan, Willis K. Samson, Samuel M. McCann, Effects of intraventricular injection of gastrin on release of LH, prolactin, TSH and GH in conscious ovariectomized rats Life Sciences. ,vol. 23, pp. 2225- 2232 ,(1978) , 10.1016/0024-3205(78)90208-4
E. Vijayan, S.M. McCann, The effects of intraventricular injection of gamma-aminobutyric acid (GABA) on prolactin and gonadotropin release in conscious female rats. Brain Research. ,vol. 155, pp. 35- 43 ,(1978) , 10.1016/0006-8993(78)90303-7
E. VIJAYAN, W. K. SAMSON, S. I. SAID, S. M. MCCANN, Vasoactive Intestinal Peptide: Evidence for a Hypothalamic Site of Action to Release Growth Hormone, Luteinizing Hormone, and Prolactin in Conscious Ovariectomized Rats* Endocrinology. ,vol. 104, pp. 53- 57 ,(1979) , 10.1210/ENDO-104-1-53
E. Vijayan, S.M. McCann, Re-evaluation of the role of catecholamines in control of gonadotropin and prolactin release. Neuroendocrinology. ,vol. 25, pp. 150- 165 ,(1978) , 10.1159/000122737
KIYOSHI MAEDA, LAWRENCE A. FROHMAN, Dissociation of Systemic and Central Effects of Neurotensin on the Secretion of Growth Hormone, Prolactin, and Thyrotropin* Endocrinology. ,vol. 103, pp. 1903- 1909 ,(1978) , 10.1210/ENDO-103-5-1903
Yuzuru Kato, Kazuo Chihara, Shozo Ohgo, Yoshiko Iwasaki, Hiromi Abe, Hiroo Imura, Growth hormone and prolactin release by substance P in rats Life Sciences. ,vol. 19, pp. 441- 446 ,(1976) , 10.1016/0024-3205(76)90052-7
E. VIJAYAN, S. M. McCANN, In vivo and in vitro effects of substance P and neurotensin on gonadotropin and prolactin release. Endocrinology. ,vol. 105, pp. 64- 68 ,(1979) , 10.1210/ENDO-105-1-64