Aryl-sulphonamidic dimers as metalloproteases inhibitors
作者： Armando Rossello , Tiziano Tuccinardi , Elisa Nuti , Elisabetta Orlandini
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摘要: The invention relates to dimeric aryl-sulphonamido compounds endowed with inhibitory activity against metalloproteases MMP, having formula (I) below (M)-L-(M′) (I), wherein M and M′, the same or different from each other, represent residues of inhibitors (II), R, R 1 , 2 3 G n have meanings reported in specification; also refers process for their preparation, pharmaceutical compositions comprising them use as therapeutic agents, particularly treatment degenerative disorders.
lens.org参考文章(19)
Fumihiko Watanabe, Takefumi Gemba, Hiroyuki Okamoto, Decomposition inhibitor for extracellular matrix of cartilage ,(2003)
Mark R. Burns, Polyamine analogues as cytotoxic agents ,(2001)
Peter G. M. Wuts, Theodora W. Greene, Protective groups in organic synthesis ,(1981)
Eric Jon Jacobsen, Louis L. Skaletzky, Bis-sulfonomides hydroxamic acids as mmp inhibitors ,(1998)
Joseph Arukwe, Duncan Wynn, Marivi Mendizabal, Sally-Ann Ricketts, Kirsty Heywood, Alan Cuthbertson, Michael Schafers, Julie Davis, Stefan Wagner, Bodo Levkau, Klaus Kopka, Hans-Jörg Breyholz, Anthony Storey, Ian Wilson, Diagnostic imaging agents with mmp inhibitory activity ,(2004)
Neil Gregory Almstead, Norman Eugene Ohler, Stanislaw Pikul, Steven Karl Laughlin, Biswanath De, Michael George Natchus, Heterocyclic side chain containing, n-substituted metalloprotease inhibitors ,(2001)
Daniel P. Getman, Joseph J. Mcdonald, Susan C. Howard, S. Zaheer Abbas, Robert M. Heintz, Gary A. Decrescenzo, Amidoaromatic ring sulfonamide hydroxamic acid compounds ,(1998)
Shashidhar Rao, Joseph G. Rico, Deborah A. Mischke, Terri L. Boehm, Gary A. DeCrescenzo, Jeffery N. Carroll, Darren J. Kassab, Sulfamato hydroxamic acid metalloprotease inhibitor ,(2000)
Gavin Alistair Whitlock, Kevin Neil Dack, Hydroxamic acid derivatives as matrix metalloprotease (mmp) inhibitors ,(1998)
Armando Rossello, Elisa Nuti, Maria Pia Catalani, Paolo Carelli, Elisabetta Orlandini, Simona Rapposelli, Tiziano Tuccinardi, Susan J. Atkinson, Gillian Murphy, Aldo Balsamo, A new development of matrix metalloproteinase inhibitors: twin hydroxamic acids as potent inhibitors of MMPs. Bioorganic & Medicinal Chemistry Letters. ,vol. 15, pp. 2311- 2314 ,(2005) , 10.1016/J.BMCL.2005.03.002