Development of nanosized silver-substituted apatite for biomedical applications: A review.
作者： Poon Nian Lim , Lei Chang , Eng San Thian
DOI: 10.1016/J.NANO.2015.03.016
关键词:
摘要: Abstract The favorable biocompatibility of hydroxyapatite (HA) makes it a popular bone graft material as well coating layer on metallic implant. To reduce implant-related infections, silver ions were either incorporated into the apatite during co-precipitation process (AgHA-CP) or underwent ion-exchange with calcium in (AgHA-IE). However, distribution AgHA-CP and AgHA-IE was different, thus affecting antibacterial action. Several studies reported that nanosized containing 0.5 wt.% provided an optimal trade-off between properties cytotoxicity. Nevertheless, AgHA nanocoatings could not function ideally due to compromise differentiation mesenchymal stem cells, evidenced reduced alkaline phosphatase, type I collagen osteocalcin. Preliminary showed biological responses be improved addition silicon. This review will discuss nanocoatings. From Clinical Editor In many patients needing material, has proven choice. Nonetheless, infections remain major concern. Hence, effective preventive measures are needed. this article, authors discussed application incorporating nanoparticles HA its use biomaterials together silica.
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