Use of beta-adrenergic inverse agonists for smoking cessation

作者: Richard A. Bond , Mitchell Glass

DOI:

关键词:

摘要: The chronic use of p-adrenergic inverse agonists such as nadolol, carvedilol, and ICI-118,551 provides an improved method for the treatment mucus hypersecretion in subjects with hypersecretion. One aspect a according to present invention is preventing or controlling respiratory tract comprising administering therapeutically effective quantity agonist subject at risk further encompasses pharmaceutical compositions additional compound.

参考文章(72)
Long P. Nguyen, Bhupinder Singh, Adedoyin A. Okulate, Victoria Y. Alfaro, Michael J. Tuvim, Burton F. Dickey, Richard A. Bond, Complementary anti-inflammatory effects of a β-blocker and a corticosteroid in an asthma model Naunyn-schmiedebergs Archives of Pharmacology. ,vol. 385, pp. 203- 210 ,(2012) , 10.1007/S00210-011-0692-0
Rianne A F De Ligt, Angeliki P Kourounakis, Ad P IJzerman, Inverse agonism at G protein‐coupled receptors: (patho)physiological relevance and implications for drug discovery British Journal of Pharmacology. ,vol. 130, pp. 1- 12 ,(2000) , 10.1038/SJ.BJP.0703311
Santosh K. Chandrasekaran, Alan S. Michaels, Siegfried Darda, Gary W. Cleary, Therapeutic system for administering clonidine transdermally ,(1977)
Graeme Milligan, Richard A. Bond, Melanie Lee, Inverse agonism: pharmacological curiosity or potential therapeutic strategy? Trends in Pharmacological Sciences. ,vol. 16, pp. 10- 13 ,(1995) , 10.1016/S0165-6147(00)88963-4
Richard W. Baker, Frank Kochinke, Carl Huang, Prolonged activity nicotine patch ,(1989)
Elena A. Rimzha, Galina V. Ustichenko, Vitaly I. Talapin, Fedor N. Kaputsky, Viktor A. Stelmakh, Tatyana L. Yurkshtovich, Pharmaceutical preparation possessing antinicotine effect and method of producing same in a gum carrier ,(1987)
David J. Enscore, Su Il Yum, James L. Osborne, Melinda Nelson, Robert M. Gale, Subsaturated nicotine transdermal therapeutic system ,(1991)
Santosh K. Chandrasekaran, Patricia S. Campbell, Dosage for coadministering drug and percutaneous absorption enhancer ,(1981)