The study of cisplatin and vinorelbine in metastatic uterine cervical cancer.
作者： Imjai Chitapanarux , Vimol Sukthomya , Pimkhuan Kamnerdsupaphon , Ekkasit Tharavichitkul , Vicharn Lorvidhaya
DOI:
关键词:
摘要: Objective: To determine the therapeutic efficacy of cisplatin in combination with vinorelbine treatment patients metastatic cervical cancer. Material and Method: a total 17 were enrolled present study. The median age was 46 years (38-65). There 6 who diagnosed as stage IVB cancer without previous treatment. planned to receive 80 mg/m2 on day 1 at 30 8 every 3 weeks. Results: Fifteen available for evaluation: 2 (13.3%) achieved complete response, (53.4%) partial responses, (20%) stable diseases progression disease. Myelosuppression major toxicity. Grade 3-4 toxicities include 66.7% hemoglobin 26.7% neutropenia. No other significant side effects found. Conclusion: Cisplatin-vinorelbine is an active well-tolerated regimen carcinoma. These results require confirmation. Keywords: Uterine neoplasms, Cisplatin, Vinblastine, Vinorelbine
参考文章(23)
A J Wozniak, J J Crowley, S P Balcerzak, G R Weiss, C H Spiridonidis, L H Baker, K S Albain, K Kelly, S A Taylor, D R Gandara, R B Livingston, Randomized trial comparing cisplatin with cisplatin plus vinorelbine in the treatment of advanced non-small-cell lung cancer: A Southwest Oncology Group study Journal of Clinical Oncology. ,vol. 16, pp. 2459- 2465 ,(1998) , 10.1200/JCO.1998.16.7.2459
Sandro Pignata, Giustino Silvestro, Ettore Ferrari, Luigi Selvaggi, Francesco Perrone, Antonio Maffeo, Pasquale Frezza, Giovanni Di Vagno, Gennaro Casella, Paolo Ricchi, Gennaro Cormio, Ciro Gallo, Francesco Iodice, Frank Romeo, Roberto Fiorentino, Giovanni Fortuna, Sergio Tramontana, Phase II Study of Cisplatin and Vinorelbine as First-Line Chemotherapy in Patients With Carcinoma of the Uterine Cervix Journal of Clinical Oncology. ,vol. 17, pp. 756- 760 ,(1999) , 10.1200/JCO.1999.17.3.756
P Bonomi, J A Blessing, F B Stehman, P J DiSaia, L Walton, F J Major, Randomized trial of three cisplatin dose schedules in squamous-cell carcinoma of the cervix: a Gynecologic Oncology Group study. Journal of Clinical Oncology. ,vol. 3, pp. 1079- 1085 ,(1985) , 10.1200/JCO.1985.3.8.1079
J A Lacava, B A Leone, M Machiavelli, A O Romero, J E Perez, Y L Elem, R Ferreyra, G Focaccia, G Suttora, M A Salvadori, M A Cuevas, L R Acuña, J R Acuña, M Langhi, S Amato, J Castaldi, A Arroyo, C T Vallejo, Vinorelbine as neoadjuvant chemotherapy in advanced cervical carcinoma. Journal of Clinical Oncology. ,vol. 15, pp. 604- 609 ,(1997) , 10.1200/JCO.1997.15.2.604
E. L. Kaplan, Paul Meier, Nonparametric Estimation from Incomplete Observations Springer Series in Statistics. ,vol. 53, pp. 319- 337 ,(1992) , 10.1007/978-1-4612-4380-9_25
Gregory P. Sutton, John A. Blessing, Willard Barnes, Harrison Ball, Phase II study of vinblastine in previously treated squamous carcinoma of the cervix. A Gynecologic Oncology Group study. American Journal of Clinical Oncology. ,vol. 13, pp. 470- 471 ,(1990) , 10.1097/00000421-199012000-00003
John J. Kavanagh, Larry J. Copeland, David M. Gershenson, Patton B. Saul, J.Taylor Wharton, Felix N. Rutledge, Continuous-infusion vinblastine in refractory carcinoma of the cervix: A phase II trial Gynecologic Oncology. ,vol. 21, pp. 211- 214 ,(1985) , 10.1016/0090-8258(85)90254-9
Don V. Jackson, Vernon W. Jobson, Howard D. Homesley, Charles Welander, Ervin A. Hire, Michael D. Pavy, May L. Votaw, Fred Richards, Hyman B. Muss, Vincristine infusion in refractory gynecologic malignancies. Gynecologic Oncology. ,vol. 25, pp. 212- 216 ,(1986) , 10.1016/0090-8258(86)90101-0
Vittoria Gebbia, Michele Caruso, Antonio Testa, Gaetano Mauceri, Nicolò Borsellino, Maurizio Chiarenza, Nicoletta Pizzardi, Sergio Palmeri, Vinorelbine and Cisplatin for the Treatment of Recurrent and/or Metastatic Carcinoma of the Uterine Cervix Oncology. ,vol. 63, pp. 31- 37 ,(2002) , 10.1159/000065717
J.B. Vermorken, The role of chemotherapy in squamous cell carcinoma of the uterine cervix: a review. International Journal of Gynecological Cancer. ,vol. 3, pp. 129- 142 ,(1993) , 10.1046/J.1525-1438.1993.03030129.X