Ticagrelor versus prasugrel in acute coronary syndrome patients with high on-clopidogrel platelet reactivity following percutaneous coronary intervention: a pharmacodynamic study.

作者: Dimitrios Alexopoulos , Anastasia Galati , Ioanna Xanthopoulou , Eleni Mavronasiou , George Kassimis

DOI: 10.1016/J.JACC.2012.03.050

关键词:

摘要: Objectives The study aimed to compare the antiplatelet action of ticagrelor with prasugrel in acute coronary syndrome (ACS) patients high on-treatment platelet reactivity (HTPR) while on clopidogrel after percutaneous intervention (PCI). Background Newer P2Y12 inhibitors like and provide stronger inhibition compared clopidogrel. Both agents are efficacious HTPR clopidogrel, but direct comparison between them has not yet been reported. Methods In a prospective, single-center, single-blind study, 44 (of 139 screened, 31.7%) ACS 24 h post-PCI were randomized either 90 mg twice daily or 10 once for 15 days crossover directly alternate treatment another days. was defined as units (PRU) ≥235 assessed by VerifyNow function assay. Results primary endpoint at end 2 periods lower (32.9 PRU, 95% confidence interval [CI]: 18.7 47.2) (101.3 CI: 86.8 115.7) least squares mean difference –68.3 PRU (95% –88.6 –48.1; p Conclusions exhibiting post-PCI, produces significantly higher prasugrel. (Ticagrelor Versus Prasugrel Acute Coronary Syndromes After Percutaneous Intervention; NCT01360437 )

参考文章(29)
Gianluca Campo, Giovanni Parrinello, Paolo Ferraresi, Barbara Lunghi, Matteo Tebaldi, Matteo Miccoli, Jlenia Marchesini, Francesco Bernardi, Roberto Ferrari, Marco Valgimigli, Prospective Evaluation of On-Clopidogrel Platelet Reactivity Over Time in Patients Treated With Percutaneous Coronary Intervention Journal of the American College of Cardiology. ,vol. 57, pp. 2474- 2483 ,(2011) , 10.1016/J.JACC.2010.12.047
Dimitrios Alexopoulos, Gerasimos Dimitropoulos, Periklis Davlouros, Ioanna Xanthopoulou, George Kassimis, Eleana F Stavrou, George Hahalis, Aglaia Athanassiadou, None, Prasugrel overcomes high on-clopidogrel platelet reactivity post-stenting more effectively than high-dose (150-mg) clopidogrel: the importance of CYP2C19*2 genotyping. Jacc-cardiovascular Interventions. ,vol. 4, pp. 403- 410 ,(2011) , 10.1016/J.JCIN.2010.12.011
Somjot S. Brar, Jurrien ten Berg, Rossella Marcucci, Matthew J. Price, Marco Valgimigli, Hyo-Soo Kim, Giuseppe Patti, Nicoline J. Breet, Germano DiSciascio, Thomas Cuisset, George Dangas, Impact of Platelet Reactivity on Clinical Outcomes After Percutaneous Coronary Intervention Journal of the American College of Cardiology. ,vol. 58, pp. 1945- 1954 ,(2011) , 10.1016/J.JACC.2011.06.059
Robert F. Storey, Dominick J. Angiolillo, Shankar B. Patil, Bhaloo Desai, Rosemary Ecob, Steen Husted, Hakan Emanuelsson, Christopher P. Cannon, Richard C. Becker, Lars Wallentin, Inhibitory Effects of Ticagrelor Compared With Clopidogrel on Platelet Function in Patients With Acute Coronary Syndromes: The PLATO (PLATelet inhibition and patient Outcomes) PLATELET Substudy Journal of the American College of Cardiology. ,vol. 56, pp. 1456- 1462 ,(2010) , 10.1016/J.JACC.2010.03.100
Georgios Sideris, Remy Cohen, Catherine Meuleman, Claire Bal dit Sollier, Olivier Barthélémy, Patrick Henry, Pascal Lim, Farzin Beygui, Jean-Philippe Collet, Debra Marshall, Junxiang Luo, Helene Petitjean, Ludovic Drouet, Gilles Montalescot, Prasugrel compared with high-dose clopidogrel in acute coronary syndrome. The randomised, double-blind ACAPULCO study. Thrombosis and Haemostasis. ,vol. 103, pp. 213- 223 ,(2009) , 10.1160/TH09-07-0482
Rossella Marcucci, Anna Maria Gori, Betti Giusti, Rosanna Abbate, Gian Franco Gensini, Francesco Sofi, Clopidogrel non-responsiveness and risk of cardiovascular morbidity. An updated meta-analysis. Thrombosis and Haemostasis. ,vol. 103, pp. 841- 848 ,(2010) , 10.1160/TH09-06-0418
Stefan James, Andrzej Budaj, Philip Aylward, Kristen K. Buck, Christopher P. Cannon, Jan H. Cornel, Robert A. Harrington, Jay Horrow, Hugo Katus, Matyas Keltai, Basil S. Lewis, Keyur Parikh, Robert F. Storey, Karolina Szummer, Daniel Wojdyla, Lars Wallentin, Ticagrelor Versus Clopidogrel in Acute Coronary Syndromes in Relation to Renal Function Results From the Platelet Inhibition and Patient Outcomes (PLATO) Trial Circulation. ,vol. 122, pp. 1056- 1067 ,(2010) , 10.1161/CIRCULATIONAHA.109.933796
J. T. BRANDT, S. L. CLOSE, S. J. ITURRIA, C. D. PAYNE, N. A. FARID, C. S. ERNEST, D. R. LACHNO, D. SALAZAR, K. J. WINTERS, Common polymorphisms of CYP2C19 and CYP2C9 affect the pharmacokinetic and pharmacodynamic response to clopidogrel but not prasugrel Journal of Thrombosis and Haemostasis. ,vol. 5, pp. 2429- 2436 ,(2007) , 10.1111/J.1538-7836.2007.02775.X
Robert F. Storey, Steen Husted, Robert A. Harrington, Stanley Heptinstall, Robert G. Wilcox, Gary Peters, Mark Wickens, Håkan Emanuelsson, Paul Gurbel, Peer Grande, Christopher P. Cannon, Inhibition of platelet aggregation by AZD6140, a reversible oral P2Y12 receptor antagonist, compared with clopidogrel in patients with acute coronary syndromes Journal of the American College of Cardiology. ,vol. 50, pp. 1852- 1856 ,(2007) , 10.1016/J.JACC.2007.07.058
Giuseppe Biondi-Zoccai, Marzia Lotrionte, Pierfrancesco Agostoni, Antonio Abbate, Enrico Romagnoli, Giuseppe Sangiorgi, Dominick J. Angiolillo, Marco Valgimigli, Luca Testa, Fiorenzo Gaita, Imad Sheiban, Adjusted indirect comparison meta-analysis of prasugrel versus ticagrelor for patients with acute coronary syndromes International Journal of Cardiology. ,vol. 150, pp. 325- 331 ,(2011) , 10.1016/J.IJCARD.2010.08.035