Serum complements C3 and C4 in chronic HCV infection and their correlation with response to pegylated interferon and ribavirin treatment.

摘要: Abstract Background and study aims To search for an immunological parameter that may correlate with the response to interferon (IFN) treatment is very crucial. The objective of this was levels C3 C4 complement components IFN in patients chronic hepatitis C virus (HCV) infection. Patients methods This conducted on 100 control subjects classified into three groups. Group (I) consisted 50 who were receiving showed various responses; group (II) included 25 naive treatment; (III) healthy matched age sex served as controls. Measurement level done by a quantitative turbidimetric test. at end 48th week. Results Serum found be significantly reduced all HCV infection both groups (I II) compared ( p p  = 0.025 0.05, respectively). There significant negative correlation between concentration serum alanine aminotransferase (ALT) measured simultaneously. Conclusion Higher concentrations positively correlated end-of-treatment treated ribavirin.