Synthesis of side-chain homologated analogs of 1,25-dihydroxycholecalciferol and 1,25-dihydroxyergocalciferol.
作者： M CHODYNSKI , A KUTNER
DOI: 10.1016/0039-128X(91)90052-W
关键词:
摘要: Abstract A novel synthesis of side-chain homologated analogs vitamin D isomers has been described . The allows for the insertion double bond into C-24 position side chain. key synthetic step involves coupling a new C 24 -uitamin synthon with respective fragment. method is illustrated by preparation of'(24E)-24,24a-dehydro-24,24-dihomo-1,25-di-hydroxycholecalciferol (1) and (24b R)- S)-24,24-dihomo-1,25-dihydroxyergocalciferols ( 2 3 ). Trans geometry newly formed in chain was confirmed high field nuclear magnetic resonance spectra (Steroids) 56 :311–315, 1991)
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