The effect of 2,4-dinitrophenol and related compounds on bile secretion

摘要: 1. 2,4-dinitrophenol, 2,4-dinitrophenetole, 2,4-dinitronaphthol, 4,6-dinitro-o-cresol, and to a lesser extent picric acid, produced an increase in bile flow rise body temperature the anaesthetized dog. The total biliary bromsulphalein (BSP) excretion unit time was either slightly reduced, increased or remained at its pre-injection level. 2. Picramic nitrochlorophenols 2,4-dinitrobenzaldehyde caused moderate without effect on of animal. 3. three mononitrophenols, five remaining isomeric dinitrophenols, isopicramic aminonitrophenols, phenol, 2,4-dinitroanisole, 2,4-dinitrobenzoic 2,4-dinitrobenzene sulphonic 2,4-dinitroresorcinol 4-nitracatechol had little secretion temperature. 4. It thus appears that, order for compound this type have pronounced secretion, it is necessary nitro groups positions 2 4 benzene ring, free potential hydroxyl group.