Light Therapy for Seasonal Affective Disorder with Blue Narrow-Band Light-Emitting Diodes (LEDs)

摘要: Background While light has proven an effective treatment for Seasonal Affective Disorder (SAD), optimal wavelength combination not been determined. Short (blue) demonstrated potency as a stimulus acute melatonin suppression and circadian phase shifting. Methods This study tested the efficacy of short therapy SAD. Blue emitting diode (LED) units produced 468 nm at 607 μW/cm 2 (27 half-peak bandwidth); dim red LED provided 654 34 (21 bandwidth). Patients with major depression seasonal pattern, score ≥20 on Structured Interview Guide Hamilton Depression Rating Scale-SAD version (SIGH-SAD) normal sleeping patterns (routine bedtimes between 10:00 pm midnight) received 45 minutes morning daily 3 weeks. Twenty-four patients completed following random assignment condition (blue vs. light). The SIGH-SAD was administered weekly. Results Mixed-effects analyses covariance determined that decreased scores significantly more than dimmer ( F = 6.45, p .019 average over post-treatment times). Conclusions Narrow bandwidth blue μ W/cm outperforms in reversing symptoms pattern.