Pyrrolizines: Promising scaffolds for anticancer drugs.
作者： Amany Belal , Bahaa El-Dien M. El-Gendy
DOI: 10.1016/J.BMC.2013.11.040
关键词:
摘要: Pyrrolizine derivatives constitute a class of heterocyclic compounds which can serve as promising scaffolds for anticancer drugs. The unique antitumor properties mitomycin C inspired chemists to develop different pyrrolizine systems and assess their potential activities against wide variety cancer types. Here we review the classes pyrrolizines that possess potency, with an emphasis on structure activity relationships, in effort pave way further development this area research.
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sci-hub.se 参考文章(53)
RYUICHIRO NAKAI, HARUMI OGAWA, AKIRA ASAI, KATSUHIKO ANDO, TSUTOMU AGAISUMA, SHIGEKI MAISUMIYA, SHIRO AKINAGA, YOSHINORI YAMASHITA, TAMIO MIZUKAMI, UCS1025A, a novel antibiotic produced by Acremonium sp. The Journal of Antibiotics. ,vol. 53, pp. 294- 296 ,(2000) , 10.7164/ANTIBIOTICS.53.294
Jinsuk Woo, Snorri T. Sigurdsson, Paul B. Hopkins, DNA interstrand cross-linking reactions of pyrrole-derived, bifunctional electrophiles: evidence for a common target site in DNA Journal of the American Chemical Society. ,vol. 115, pp. 3407- 3415 ,(1993) , 10.1021/JA00062A002
Wukun Liu, Jinpei Zhou, Kerstin Bensdorf, Huibin Zhang, Haoran Liu, Yubin Wang, Hai Qian, Yanchun Zhang, Anja Wellner, Gerhard Rubner, Wenlong Huang, Cancheng Guo, Ronald Gust, Investigations on cytotoxicity and anti-inflammatory potency of licofelone derivatives. European Journal of Medicinal Chemistry. ,vol. 46, pp. 907- 913 ,(2011) , 10.1016/J.EJMECH.2011.01.002
L. W. Smith, C. C. J. Culvenor, Plant sources of hepatotoxic pyrrolizidine alkaloids. Journal of Natural Products. ,vol. 44, pp. 129- 152 ,(1981) , 10.1021/NP50014A001
Wayne K. Anderson, Dennis C. Dean, Toshiyasu Endo, Synthesis, chemistry, and antineoplastic activity of alpha-halopyridinium salts: potential pyridone prodrugs of acylated vinylogous carbinolamine tumor inhibitors. Journal of Medicinal Chemistry. ,vol. 33, pp. 1667- 1675 ,(1990) , 10.1021/JM00168A021
Christophe Rochais, Thierry Cresteil, Vittoria Perri, Marie Jouanne, Aurélien Lesnard, Sylvain Rault, Patrick Dallemagne, MR22388, a novel anti-cancer agent with a strong FLT-3 ITD kinase affinity Cancer Letters. ,vol. 331, pp. 92- 98 ,(2013) , 10.1016/J.CANLET.2012.12.017
H. S. Schwartz, J. E. Sodergren, F. S. Philips, MITOMYCIN C: CHEMICAL AND BIOLOGICAL STUDIES ON ALKYLATION. Science. ,vol. 142, pp. 1181- 1183 ,(1963) , 10.1126/SCIENCE.142.3596.1181
Maria Tomasz, Mitomycin C: small, fast and deadly (but very selective) Chemistry & Biology. ,vol. 2, pp. 575- 579 ,(1995) , 10.1016/1074-5521(95)90120-5
Douglas D. Buechter, David E. Thurston, Studies on the Pyrrolizidine Antitumor Agent, Clazamycin: Interconversion of Clazamycins A and B Journal of Natural Products. ,vol. 50, pp. 360- 367 ,(1987) , 10.1021/NP50051A004
Haruki Niwa, Takeshi Ogawa, Osamu Okamoto, Kiyoyuki Yamada, Alkylation of nucleosides by dehydromonocrotaline, the putative toxic metabolite of the carcinogenic pyrrolizidine alkaloid monocrotaline Tetrahedron Letters. ,vol. 32, pp. 927- 930 ,(1991) , 10.1016/S0040-4039(00)92122-1