Limb Muscle Dysfunction in COPD: Effects of Muscle Wasting and Exercise Training

摘要: PURPOSE: Lower-limb muscle weakness has often been reported in COPD, and contributes to exercise intolerance. Controversial information is available regarding upper-limb adaptations the influence of wasting on weakness. We investigated leg arm function 59 stable COPD patients (GOLD stage III) with preserved fat-free mass (FFM) 28 reduced FFM relative age- sex-matched healthy control subjects studied effects 8 wk whole-body training. METHODS: was measured bioelectrical impedance analysis. Isokinetic quadriceps (F-leg) biceps strength (F-arm), as well (E-leg) endurance (E-arm) were determined a Biodex dynamometer. Exercise training consisted cycle ergometry, treadmill walking, weight training, gymnastics during 5 d.wk. RESULTS: F-leg (76.2 +/- 3.6 vs 118.2 6.3 N.m, P < 0.001) F-arm (25.6 1.3 38.1 2.1 significantly similarly patient group compared controls. Also, E-leg (-2.13 0.12 -1.61 0.11, 0.01), but not E-arm (-2.72 0.11 -2.47 0.13 NS), decreased patients. (62.4 4.3 82.8 4.7 or endurance, FFM-depleted non-FFM-depleted Whereas after increased by 20% whole group, remained unchanged. CONCLUSION: Lower- dysfunction observed patients, irrespective presence depletion. Generalized suggests systemic muscular involvement, although poor response performance indicative for intrinsic differences between muscles.