摘要: Dietary restriction regimens are commonly employed to facilitate weight loss in obese individuals. The dietary regimen most frequently implemented is daily calorie (CR), which involves decreasing energy intake by a certain percentage daily. Another employed, although far less commonly, alternate day fasting (ADF). ADF include “feed day” where food consumed ad libitum, alternated with “fast day”, partially reduced. Adipose tissue physiology plays an important role mediating the risk of obesity-related disorders. present review examines ability CR versus improve parameters adipose biology (body weight, regional fat distribution, and fat-cell derived hormone levels) overweight humans. Interactions between these various physiological parameters, how they combine impact disease risk, also discussed.