Calcium-channel modulators for cardiovascular disease.

摘要: It is generally accepted that hypertension doubles the risk of cardiovascular disease, which coronary heart disease most common and lethal. Hypertension a predisposing factor for development stroke, peripheral arterial failure end-state renal disease. Atherosclerosis-causing related to severity hypertension. Inhibition calcium entry reduces active tone vascular smooth muscle produces vasodilatation. This pharmacological action has been basis use calcium-channel blockers (CCBs) management Other drug families may achieve this: diuretics, beta-blockers, angiotensin-converting enzyme inhibitors, angiotensin-receptor antagonists. Cardiovascular hypertrophy atherosclerosis are major complications high blood pressure. Cardiac considered as an independent associated with abnormalities diastolic function can result in failure. Atherosclerosis activation innate immunity. expressing itself not only but cerebrovascular By impairing physiological vasomotor function, includes ultimately necrosis myocardium. CCBs reduce Do they prevent progress main hypertension? question matter present paper.