Apoptotic Events in Blood Cells

作者: J.A. Rosado

DOI: 10.1007/978-1-4020-9873-4_6

关键词:

摘要: Cells undergo apoptotic events during development, tissue homeostasis or disease and are subsequently cleared by phagocytes, inducing changes in the immune response. Lymphocyte apoptosis is responsible for of cells plays an essential role elimination autoreactive lymphocytes. Apoptosis also modulates neutrophil life span, regulating balance between their function as effectors system clearance potentially harmful cells. Programmed mammalian red blood death, eryptosis, a special form that shows all features apoptosis, except nuclear condensation. Similarly, platelets, small, anuclear cytoplasmic fragments, develop regulates platelet span. Apoptotic events, which enhanced mature megakaryocytes, precursors, have been proposed major force driving proplatelet formation release. In addition to platelets apoptotic-like including rapid reversible activation caspase 3, Ca2+ signalling aggregation independently programmed cell death. Finally elevated oxidative stress peripheral cells, such lymphocytes, biomarker Alzheimer disease. This chapter describes physiological pathological implications

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