Allergic diseases: From bench to clinic - Contribution of the discovery of interleukin-5.

摘要: T helper 2 cells produce a number of cytokines including inteleukin (IL)-5, IL-4 and IL-13. Group innate lymphoid (ILC2s) also IL-5 under sterile conditions. is interdigitating homodimeric glycoprotein member the four α helical bundle motifs conserved among hematopoietic cytokines. exerts its effects on target via receptor (IL-5R), composed an IL-5R βc subunit. The membrane proximal proline-rich motif cytoplasmic domain both subunits essential for signal transduction. Although was initially identified by ability to support growth terminal differentiation mouse B into antibody-secreting cells, recombinant pleiotropic activities various cells. For example, now recognized as major maturation factor eosinophils in mice humans. Overexpression significantly increases eosinophil numbers antibody levels vivo, while lacking functional gene or display developmental impairments cell lineages. In mice, role IL-5/IL-5R system production secretion Immunoglobulin (Ig) M IgA mucosal tissues has been reported. protect against invading pathogens virus, bacteria helminthes, they are involved pathogenesis diseases, such food allergy, asthma, inflammatory bowel diseases. recent expansion our understanding context IL-5-producing ILC2s activation eosinophil-dependent diseases led advances therapeutic options. A new therapy currently invetigarion clinical trials uses humanized monoclonal antibodies IL-5R. this review, we summarize current functions receptor, regulation potential anti-IL-5 anti-eosinophil (IL-5R) antibodies.