Early or Up-Front Radiotherapy Improved Survival of Localized Extranodal NK/T-Cell Lymphoma, Nasal-Type in the Upper Aerodigestive Tract
作者： Mei-juan Huang , Yu Jiang , Wei-ping Liu , Zhi-ping Li , Mei Li
DOI: 10.1016/J.IJROBP.2007.05.073
关键词:
摘要: Purpose To investigate the role of early or up-front radiotherapy (RT), optimal RT dose required to achieve appropriate treatment outcome and prognostic factors for patients with localized extranodal NK/T-cell lymphoma, nasal-type, in upper aerodigestive tract. Methods Materials Eighty-two were reviewed. Eight treated chemotherapy (CT) alone, 9 received 65 given combined modality CT (CMT). Of those 74 receiving RT, 31 whereas was initial therapy 43 41 RT. Results Five-year overall survival (OS) disease-free (DFS) 52.3% 39.2%, respectively. only independent factor both OS DFS at univariate multivariate level. The 5-year better ≥54 Gy as compared that p = 0.019; 60.3% vs. 33.4%, 0.004). Up-front presented Stage I when followed by (5-year 90.0% 48.9%, 0.012; 78.7% 39.9%, 0.021). Conclusion Early had an essential improved recommended tumor least 54 Gy. may yield more benefits on disease.
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