Long Non-coding RNA PVT1 as a Prognostic and Therapeutic Target in Pediatric Cancer.

摘要: In recent decades, biomedical research has focused on understanding the functionality of human translated genome, which represents a minor part all genetic information transcribed from genome. However, researchers have become aware importance non-coding RNA species that constitute vast majority transcriptome. addition to their crucial role in tissue development and homeostasis, mounting evidence shows be deregulated functionally contributing progression different types disease including cancer both adults children. Small RNAs (i.e., microRNA) are vanguard clinical revealed could used as biomarkers or new therapeutic targets. Furthermore, many more expectations been raised for long RNAs, by far largest fraction transcripts, still fewer findings into applications. this review, we center PVT1, large complex usually confers oncogenic properties tumor types. We focus compilation early advances field pediatric tumors often lags behind improvements adult tumors, provide rationale continue studying PVT1 possible functional contributor malignancies potential prognostic marker target.