Current chemotherapy of human African trypanosomiasis.

摘要: Human African trypanosomiasis is a fatal disease caused by Trypanosoma brucei gambiense and rhodesiense that has re-emerged in recent years. However, very little progress been made the development of new drugs against this disease. Most still use were developed one or more decades ago, are generally toxic limited effectiveness. The most recently introduced compound, eflornithine, only useful sleeping sickness T. b. gambiense, prohibitively expensive for developing countries. We present here an overview today's approved clinically used