Activation of cardiac vagal afferents in ischemia and reperfusion. Prostaglandins versus oxygen-derived free radicals.

摘要: Myocardial ischemia and reperfusion can evoke excitation of cardiac vagal nerve endings activation a cardiogenic depressor reflex (Bezold-Jarisch effect). We postulate that oxygen-derived free radicals, which are known to be produced during prolonged reperfusion, contribute this afferent excitation. recorded activity from 47 chemosensitive fibers in 31 rats; the these were located left ventricle. Chemosensitive identified with topical applications capsaicin (10 micrograms) surface heart. Reactivity radicals was assessed by application H2O2 (3 9 mumol). Activity 30 minutes occlusion anterior descending coronary artery (LAD) 10 subsequent reperfusion. The within ischemic zone increased first 2 LAD 2.2 +/- 0.4 4.3 0....