Adjuvanting an inactivated influenza vaccine with conjugated R848 improves the level of antibody present at 6 months in a nonhuman primate neonate model

摘要: Generation of a potent antibody response that can be sustained over time is highly challenging in young infants. Our previous studies using nursery-reared nonhuman primate model identified R848 conjugated to inactivated influenza virus as immunogenic vaccine for neonates. Here we determined the effectiveness this mother-reared infants well its ability promote improved responses at 6 months compared vaccination absence R848. In agreement with our nursery study, induced higher neonates non-adjuvanted vaccine. Further, increase relative by was maintained suggesting increased secreting cells resulted from inclusion production were capable surviving long term. There no significant difference quality (i.e. neutralization or affinity), beneficial effect during likely manifest early generation cells.