Chemotherapy of experimental transitional-cell carcinoma.
作者： Jean B. Dekernion , Mark S. Soloway , Lester Persky
DOI: 10.1016/0090-4295(74)90110-1
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摘要: Abstract Transitional-cell carcinoma of the bladder has been induced by chronic oral administration N-[4-(5-nitro-2-uryl)-2-thiazolyl] formamide (FANFT) in C3H/He mice, and successfully transplanted syngeneic animals. Evaluation effectiveness several chemotherapeutic agents on this tumor indicated that cyclophosphamide cis-diammine diehloroplatinum (CACP) significantly inhibited growth prolonged median survival time tumor-bearing When administered before formation palpable tumors, completely prevented implants 100 per cent animals; when after larger, all animals produced a “cure” 45 cent. Combination chemotherapy with CACP was more effective than either drug used as single agent. Adriamycin, daetinomycin, mitomycin C individually exhibited limited activity while 5 fluorouracil, CCNU (1–2 choloroethyl-3-cyclohexyl-l-nitrosourea), BCNU (1,3-bus [2-chloroethyl]-1-nitrosourea), methrotrexate, hydroxyurea were ineffective against tumor. The consistent pattern, histologic similarity to cancer human beings, successful propagation animals, make FANFT-induced suitable model for beings.
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