Chronic Effects of Cannabis Use on the Auditory Mismatch Negativity

摘要: Background Cannabis use is associated with the development of psychotic symptoms and increased risk for schizophrenia. The mismatch negativity (MMN) a brain event-related potential marker change detection thought to index glutamatergic N -methyl-D-aspartate receptor-mediated neurotransmission, which known be deficient in This study examined auditory MMN otherwise healthy chronic cannabis users compared nonuser control subjects. Methods Forty-two 44 subjects completed multi-feature paradigm, included duration, frequency, intensity deviants (deviants 6%; standards 82%). was between as well long- short-term age- gender-matched Associations MMN, measures, were examined. Results amplitude significantly reduced frequency but not duration or overall relative Frequency similarly attenuated short- long-term Long-term also exhibited this correlated exposure psychotic-like experiences during intoxication. In users, younger age onset regular greater symptomatic distress. Conclusions These results suggest impaired sensory memory that might reflect receptor dysfunction users. pattern alterations differed from typically observed patients schizophrenia, indicating overlapping distinct underlying pathology.