Experimental Analysis of Hormone Actions on the Hypothalamus, Anterior Pituitary, and Ovary

摘要: The history of efforts to understand the factors that regulate cyclic gonadal function actually starts with research on a somewhat different problem. In early 1900s, investigators such as Steinach (reviewed in Moore and Price, 1932) were interested problem organ transplantation. attempted transplant testes into intact female rats ovaries male rats. These transplants invariably failed become functional or “take.” However, when host animal was gonadectomized, transplantation heterologous gonad said be more successful. Somewhat later, Lipschutz (1925) transplanted guinea pigs. He stated time required stimulate mammary growth much greater than graft made castrated males. Furthermore, ovarian grafts “take” (in terms stimulating gland growth) did so almost immediately male’s removed. derived idea removal led an “unbolting” function.