Maternal care modulates the febrile response to lipopolysaccharide through differences in glucocorticoid receptor sensitivity in the rat.

摘要: Early life adversity increases the risk for later infection. The febrile response is a potent mechanism to combat We found that variations in maternal care influence 50µg/kg lipopolysaccharide (LPS) challenge adult male rats. Offspring from low-licking/grooming (LG) mothers had an increased compared offspring high-LG challenged with LPS. Low-LG reduced plasma IL-6 at one and two hours post offspring. gene expression anterior hypothalamus was induced following LPS low-LG but not challenge. Occupancy of transcription factor nuclear kappa-light-chain-enhancer activated B cells (NFκB) promoter region greater treated than These findings suggest activation thermoregulatory neurons corticosterone levels they enhanced glucocorticoid receptors (GR) spleen Enhanced glucocorticoids receptor sensitivity associated induction early Challenge RU-486 prior eliminated differences between high mothers. Individual GR may modulate challenge, exerting long-term on capacity recover