Targeted delivery of “copper carbonate” nanoparticles to cancer cells in vivo

摘要: Various metal based nanoparticles such as Zn, Co and Cu are well known to have an anticancer effect. In targeting these nanoparticles, it is a great challenge minimize the toxicity normal cells. Folate receptors expressed in variety of cancer Folic acid mediated accepted technique for therapeutics. The purpose this study explore effect novel copper carbonate (CuCO3) their targeted delivery cells vitro vivo. We synthesized CuCO3 by precipitation method, they were characterized using various biophysical techniques. These (18–20 nm) induced DNA damage disrupted mitochondrial membrane, finally cell death was apoptosis. Additionally, folic conjugated deliver them specifically To efficacy targeting, folate receptor knockdown HeLa developed sh-RNA also further tested on mouse model. can be effective therapeutic agent expressing cells, therefore