Cytochrome P450-Like Biomimetic Oxidation Catalysts Based on Mn Porphyrins as Redox Modulators

摘要: In this chapter, we put forward an emerging concept on which the therapeutic action of some Mn porphyrins (MnPs) used in vivo may not be restricted to SOD-type antioxidant catalytic role per se, but involve P450-type oxidation catalysis. ROS/RNS-type oxidants, such as hydrogen peroxide, hydroperoxides, and hypochlorite, are all classic oxygen donors chemistry literature metalloporphyrin-based systems, mostly unavailable Pubmed database. Whereas association MnPs a pro-oxidant is rather recent, have been explored biomimetic oxidant catalysts for more than three decades fields Merging biological new discoveries typical findings would bring breath fresh air both biology with very positive prospects medicinal development MnP-based therapeutics. The chapter includes, thus, brief description general mechanism cytochromes P450 related heme-containing enzymes, peroxidases (e.g., horseradish peroxidase) followed by presentation selected aspects 30+ years models. It goal provide full account highlight main features MnP reactions that become relevant interpreting results use redox-active