Serotonin-2 receptors and human sleep: effect of a selective antagonist on EEG power spectra.
作者： Hans-Peter Landolt , Viola Meier , Helen J Burgess , Luca A Finelli , Françoise Cattelin
DOI: 10.1016/S0893-133X(99)00052-4
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摘要: To investigate the effect on sleep EEG, a 1-mg oral dose of SR 46349B, novel 5-HT2 antagonist, was administered three hours before bedtime. The drug enhanced slow wave (SWS) and reduced stage 2 without affecting subjective quality. In nonREM (NREMS) EEG slow-wave activity (SWA; power within 0.75–4.5 Hz) increased spindle frequency (SFA; 12.25–15 decreased. relative NREMS spectrum showed bimodal pattern with main peak at 1.5 Hz secondary 6 Hz. A regional analysis based bipolar derivations along antero-posterior axis revealed significant ‘treatment’ × ‘derivation’ interactions 9–16 range. enhancing SWA attenuating SFA, receptor antagonist mimicked deprivation, whereas differed.
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