Nitrogen-containing bisphosphonate, YM529/ONO-5920, inhibits macrophage inflammatory protein 1α expression and secretion in mouse myeloma cells
作者： Masanobu Tsubaki , Chisato Kato , Minori Nishinobo , Mitsuhiko Ogaki , Takao Satou
DOI: 10.1111/J.1349-7006.2007.00651.X
关键词:
摘要: Macrophage inflammatory protein 1 alpha (MIP-1 alpha) is detected at high concentrations in patients with multiple myeloma, and it thought to play an important role the etiology of myeloma osteolysis. Thus, we investigated whether or not YM529/ONO-5920, a new bisphosphonate, inhibited MIP-1 mRNA expression in, secretion from, mouse cells. When cells were stimulated by lipopolysaccharide, increased observed. YM529/ONO-5920 concentration-dependent manner. A transient increase phosphorylation extracellular-regulated kinase 1/2 (ERK1/2) Akt was observed after lipopolysaccharide stimulation. After given, there no ERK1/2 Akt. These results indicated that through blocking signaling pathway Ras/mitogen-activated kinase/ERK Ras/phosphatidylinositol-3 kinase/Akt. Accordingly, appears have promise for use effective future therapy osteolysis cell growth depends on alpha.
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