Antibiotic-impregnated acrylic bone cement

摘要: In vitro and in vivo experiments were performed to study the antibacterial mechanical properties of Simplex Palacos acrylic bone cements utilized for production cement-antibiotic composites. Acrylic cement without antibiotic had no bacteriostatic effect on Staphylococcus aureus, Escherichia coli, Pseudomonas. Oxacillin, cefazolin, gentamicin are stable released a microbiologically active form. The three antibiotics diffused from larger amounts daily significantly longer time than Simplex. Mechanical tests demonstrated that admixture influence compressive diametral tension strengths cement. Bacteriostatic concentrations oxacillin wound hematomas measured fourteen days after implantation an oxacillin-Simplex composite dogs. High bactericidal surrounding twenty-one implantation.