Cytokines and chemokines in respiratory secretion and severity of disease in infants with respiratory syncytial virus (RSV) infection.
作者： Allan Hornsleth , Lotte Loland , Lars B Larsen
DOI: 10.1016/S1386-6532(01)00159-7
关键词:
摘要: Abstract Background : little is known about inflammatory mediators (IM); like cytokines, chemokines and receptors; in respiratory secretion as possible indicators of the severity syncytial virus (RSV) disease. Nor have systematic studies been published on ratios between IM such indicators. Objective to define role RSV Study design 46 infants aged 0–9 months with acute infections were studied. Prematurity (PM) and/or underlying disease (UD) present 11 them. The concentrations seven different measured by ELISA samples nasopharyngeal secretions (NPS), four cytokines; IL-1, IL-6, IL-10 TNF-α; cytokine receptor TNF-R1 chemokines; IL-8 RANTES. 21 calculated from these concentrations. patients assigned a clinical score (CS) ranging 0 3 according Results when 25 severe (CS 2–3) mild 0–1) compared respect ratios, three related disease: IL-1/RANTES, IL-8/RANTES TNF-R1/RANTES. When 12 16 disease, omitting more than 5 age PM UD, following TNF-R1/RANTES, RANTES/IL-10. Conclusion studied, TNF-R1/RANTES was greatest consistency.
elsevier.com
sci-hub.se 参考文章(26)
B König, W König, H Galatti, H Werchau, R Arnold, Cytokine (IL-8, IL-6, TNF-alpha) and soluble TNF receptor-I release from human peripheral blood mononuclear cells after respiratory syncytial virus infection. Immunology. ,vol. 85, pp. 364- 372 ,(1995)
John I. Gallin, Ralph Snyderman, Ira M. Goldstein, Inflammation: Basic principles and clinical correlates ,(1988)
A. MARC HARRISON, CYNTHIA A. BONVILLE, HELENE F. ROSENBERG, JOSEPH B. DOMACHOWSKE, Respiratory Syncytical Virus-induced Chemokine Expression in the Lower Airways Eosinophil Recruitment and Degranulation American Journal of Respiratory and Critical Care Medicine. ,vol. 159, pp. 1918- 1924 ,(1999) , 10.1164/AJRCCM.159.6.9805083
Allan Hornsleth, Birgitte Friis, Peter Andreas Krasilnikof, Detection of respiratory syncytial virus in nasopharyngeal secretions by a biotin-avidin ELISA more sensitive than the fluorescent antibody technique. Journal of Medical Virology. ,vol. 18, pp. 113- 117 ,(1986) , 10.1002/JMV.1890180203
Debra A. Tristram, Wesley Hicks, Robert Hard, Respiratory Syncytial Virus and Human Bronchial Epithelium Archives of Otolaryngology-head & Neck Surgery. ,vol. 124, pp. 777- 783 ,(1998) , 10.1001/ARCHOTOL.124.7.777
S. Biswas, J. S. Friedland, D. G. Remick, E. G. Davies, M. Sharland, Elevated plasma interleukin 8 in respiratory syncytial virus bronchiolitis. Pediatric Infectious Disease Journal. ,vol. 14, pp. 919- 920 ,(1995) , 10.1097/00006454-199510000-00026
ALLAN HORNSLETH, BENT KLUG, MARTA NIR, JENS JOHANSEN, KIRSTEN S. HANSEN, LAURIDS S. CHRISTENSEN, LARS B. LARSEN, Severity of respiratory syncytial virus disease related to type and genotype of virus and to cytokine values in nasopharyngeal secretions Pediatric Infectious Disease Journal. ,vol. 17, pp. 1114- 1121 ,(1998) , 10.1097/00006454-199812000-00003
C Lindgren, J Grögaard, Reflex apnoea response and inflammatory mediators in infants with respiratory tract infection Acta Paediatrica. ,vol. 85, pp. 798- 803 ,(1996) , 10.1111/J.1651-2227.1996.TB14154.X
Georges Herbein, William A. O'brien, Tumor Necrosis Factor (TNF)–α and TNF Receptors in Viral Pathogenesis Experimental Biology and Medicine. ,vol. 223, pp. 241- 257 ,(2000) , 10.1046/J.1525-1373.2000.22335.X
J R Panuska, R Merolla, N A Rebert, S P Hoffmann, P Tsivitse, N M Cirino, R H Silverman, J A Rankin, Respiratory syncytial virus induces interleukin-10 by human alveolar macrophages. Suppression of early cytokine production and implications for incomplete immunity. Journal of Clinical Investigation. ,vol. 96, pp. 2445- 2453 ,(1995) , 10.1172/JCI118302