Angiotensin II and aldosterone receptor binding in rat heart and kidney: response to chronic angiotensin II or aldosterone administration.

摘要: Angiotensin II (AII) and mineralocorticoid receptors (MRs) have been identified in the mammalian heart kidney. Their response to chronic elevations circulating AII or aldosterone (ALDO) (or both) is unknown either primary secondary hyperaldosteronism. Nonendothelial angiotensin-converting enzyme (ACE) activity has found fibrous tissue that involves intramyocardial coronary arteries microscopic scarring. Whether this ACE could affect MRs area of myocardial fibrosis likewise unknown. To address these questions, we monitored MR binding rat kidney after ALDO infusion. All receptor were localized by vitro autoradiography with 125I-[Sar1, Ile8]-labeled [1,2,6,7 3H]-labeled ALDO, respectively. characterize subtypes, a type I antagonist (DuP753) (PD 123177) was used. Four experimental groups examined: unoperated, untreated, age- sex-matched controls; uninephrectomized control rats receiving high sodium diet; animals received (9 micrograms/hr sc) for 2, 4, 6, 8 weeks; on diet (0.75 microgram/hr similar periods time.(ABSTRACT TRUNCATED AT 250 WORDS)