The influence of caffeine on the activity of moclobemide, venlafaxine, bupropion and milnacipran in the forced swim test in mice.

摘要: Abstract Aims Worrying data indicate that excessive caffeine intake applies to patients suffering from mental disorders, including depression. It is thus possible demonstrate the usefulness of and its derivatives in treatment The main goal present study was evaluate influence (5 mg/kg) on activity moclobemide (1.5 mg/kg), venlafaxine (1 mg/kg), bupropion (10 mg/kg), milnacipran (1.25 mg/kg). Moreover, we assessed their serum brain levels using high-performance liquid chromatography. Main methods experiment carried out naive adult male Albino Swiss mice. Caffeine tested drugs were administered intraperitoneally. selected antidepressant evaluated forced swim test (FST). Locomotor estimated verify exclude false positive/negative results. To assess studied drugs, concentrations determined murine brains Key findings potentiated all antidepressants examined FST observed effects not due increase locomotor animals. Only case co-administration an increased concentration without affecting brain. Significance potentiates different chemical groups. interactions with venlafaxine, occur pharmacodynamic phase, whereas interaction caffeine–milnacipran occurs, at least partially, pharmacokinetic phase.