Association Between Amyloid Accumulation and Sleep in Patients With Idiopathic REM Sleep Behavior Disorder.

摘要: Background and Objectives: Amyloid-beta protein may lead to sleep disturbance eventually develop cognitive impairment. Idiopathic rapid eye movement (REM) behavior disorder (iRBD) is a predictor of neurodegeneration, yet there have been limited studies evaluating the relationship between decline amyloid accumulation in iRBD patients. The aim this study investigate clinical characteristics patients its association with deposition. Methods: We enroll 23 (mean age, 65.8 years; male, 73.9%), their mean history clinically suspected RBD was 6.5 years. All underwent 18F-flutemetamol PET completed polysomnography (PSG) questionnaires. Patients were classified into two groups according deposition as positive negative. Clinical parameters compared correlated deposition, calculated standardized uptake value ratio (SUVR). Results: Four (17.4%) revealed be positive, they showed increased percentage wake after onset (WASO), stage N1, N2 worse on Stroop Word Color Test negative Global SUVR total time, efficiency, WASO, N1 sleep, these associated part default mode network brains such orbitofrontal, dorsolateral pre-frontal, left temporal areas. Conclusion: quality than without amyloid. Relationship fragmented crucial elucidate disease progress iRBD.