Computer-based Cognitive Training for Mild Cognitive Impairment: Results from a Pilot Randomized, Controlled Trial

摘要: We performed a pilot randomized, controlled trial of intensive, computer-based cognitive training in 47 subjects with mild impairment. The intervention group exercises specifically designed to improve auditory processing speed and accuracy for 100 min/d, 5 d/wk 6 weeks; the control more passive computer activities (reading, listening, visuospatial game) similar amounts time. Subjects had mean age 74 years 60% were men; 77% successfully completed training. On our primary outcome, Repeatable Battery Assessment Neuropsychological Status total scores improved 0.36 standard deviations (SD) (P=0.097) compared 0.03 SD (P=0.88) nonsignificant difference between groups 0.33 (P=0.26). 12 secondary outcome measures, most differences not statistically significant. However, we observed pattern which effect sizes verbal learning memory measures tended favor whereas language function group, raises possibility that these programs may have domain-specific effects. conclude mental activity is feasible impairment larger trials are warranted.