Facile synthesis of photolabile dendritic-unit-bridged hyperbranched graft copolymers for stimuli-triggered topological transition and controlled release of Nile red
作者： Bin Mo , Huanhuan Liu , Xiangdong Zhou , Youliang Zhao
DOI: 10.1039/C5PY00132C
关键词:
摘要: Different from hyperbranched star-like polymers and dendritic brushes, dendritic-unit-bridged graft copolymers (DHGCs) with branching point linked branches linear grafts can be regarded as a new subclass of hyperbranched-graft-linear copolymers. This study aims at the synthesis properties photocleavable DHGCs comprising oligomeric composed poly(ethylene glycol) methyl ether acrylate (PEGA) units, poly(e-caprolactone) (PCL) o-nitrobenzyl ester (ONBE) moieties in unit. Based on multifunctional inimer 3-((2-acryloyloxymethyl-2-hydroxymethyl)propionyloxy)methyl-2-nitrobenzyl 4-cyano-4-(phenylcarbonothioylthio)pentanoate (ANCP), functional were controllably synthesized via two step reactions. RAFT copolymerization afforded poly(ANCP-co-PEGA) (PAP), followed by CL polymerization to achieve PAP-g-PCL. Upon photo-cleavage, PAP was converted into polymers, PAP-g-PCL readily degraded mixtures linear, star polymers. With increasing UV irradiation time, micelles gradually evolved vesicles multicompartment due photo-triggered cleavage reaggregation. normal on-demand irradiation, release kinetics for controlled Nile red copolymer aggregates could tuned wide range, revealing great potential smart drug delivery systems. affords versatile method construct photolabile DHGCs, which opens up route explore unique novel topological
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