Maintenance therapies in bipolar disorders.

摘要: Gitlin M, Frye MA. Maintenance therapies in bipolar disorders. Bipolar Disord 2012: 14 (Suppl. 2): 51–65. © 2012 The Authors. Journal compilation John Wiley & Sons A/S. Objective:  disorder is an inherently recurrent disorder, requiring maintenance preventive treatments the vast majority of patients. authors review data on highlighting controlled trial literature. Methods:  Literature using PubMed, Medline, and a hand search relevant literature. Results:  Over last decade, number effective for have been developed with evidence base second-generation antipsychotics some anticonvulsants. Increasing numbers patients, therefore, are appropriately treated multiple medications as regimen. For medications, treatment has demonstrated randomized trials both monotherapy combination other mood stabilizers. Lithium continues our oldest well-established somewhat better efficacy preventing mania than depression. Lamotrigine, olanzapine, quetiapine bimodal depression, although lamotrigine’s more robust depression olanzapine’s greater mania. Aripiprazole, ziprasidone, risperidone long-acting injection all prevent mania, but not Less investigations suggested stabilization carbamazepine, oxcarbazepine, adjunctive psychotherapy. Conclusions:  Despite agents optimal regimens still evidence-based therapy individualized creative algorithms.