Inefficacy of Immediate Node Dissection in Stage 1 Melanoma of the Limbs
作者： U. Veronesi , J. Adamus , D. C. Bandiera , I. O. Brennhovd , E. Caceres
DOI: 10.1056/NEJM197709222971202
关键词:
摘要: From September, 1967, to January, 1974, a clinical trial was carried out by the WHO Melanoma Group evaluate efficacy of elective lymph-node dissection in treatment malignant melanoma extremities with clinically uninvolved regional lymph nodes. Treatment prospectively randomized: 267 patients excision primary and immediate regional-lymph-node 286 at time appearance metastases. The statistical analysis showed no difference survival between two groups patients, regardless how data were analyzed (according sex, site origin, maximum diameter tumor or Clark's level Breslow's thickness). Elective malanoma limbs does not improve prognosis is recommended when can be followed intervals three months.
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