A comparison of the antiplatelet effects of prasugrel and high-dose clopidogrel as assessed by VASP-phosphorylation and light transmission aggregometry.

作者: Christopher D Payne , Ying G Li , Nagy A Farid , John T Brandt , David S Small

DOI: 10.1160/TH07-09-0555

关键词:

摘要: … , by overnight courier to Esoterix ClinicalTrial Services, Brentwood, TN, USA, for analysis. VASP was measured by … antibody specific for phosphorylated VASP, followed by a secondary …

参考文章(39)
Paul A. Gurbel, Kevin P. Bliden, Waiel Samara, Jason A. Yoho, Kevin Hayes, Mulugeta Z. Fissha, Udaya S. Tantry, Clopidogrel effect on platelet reactivity in patients with stent thrombosis: results of the CREST Study. Journal of the American College of Cardiology. ,vol. 46, pp. 1827- 1832 ,(2005) , 10.1016/J.JACC.2005.07.056
Gilles Montalescot, Georges Sideris, Catherine Meuleman, Claire Bal-dit-Sollier, Nicolas Lellouche, Ph Gabriel Steg, Michel Slama, Olivier Milleron, Jean-Philippe Collet, Patrick Henry, Farzin Beygui, Ludovic Drouet, ALBION Trial Investigators, A randomized comparison of high clopidogrel loading doses in patients with non-ST-segment elevation acute coronary syndromes: the ALBION (Assessment of the Best Loading Dose of Clopidogrel to Blunt Platelet Activation, Inflammation and Ongoing Necrosis) trial. Journal of the American College of Cardiology. ,vol. 48, pp. 931- 938 ,(2006) , 10.1016/J.JACC.2006.04.090
Gunther Hollopeter, Hans-Michael Jantzen, Diana Vincent, Georgia Li, Laura England, Vanitha Ramakrishnan, Ruey-Bing Yang, Paquita Nurden, Alan Nurden, David Julius, Pamela B. Conley, Identification of the platelet ADP receptor targeted by antithrombotic drugs. Nature. ,vol. 409, pp. 202- 207 ,(2001) , 10.1038/35051599
Christian Gachet, None, ADP receptors of platelets and their inhibition. Thrombosis and Haemostasis. ,vol. 86, pp. 222- 232 ,(2001) , 10.1055/S-0037-1616220
P Savi, JM Pereillo, MF Uzabiaga, J Combalbert, C Picard, JP Maffrand, M Pascal, JM Herbert, None, Identification and biological activity of the active metabolite of clopidogrel. Thrombosis and Haemostasis. ,vol. 84, pp. 891- 896 ,(2000) , 10.1055/S-0037-1614133
G Kauffenstein, W Bergmeier, A Eckly, P Ohlmann, C Leon, JP Cazenave, B Nieswandt, C Gachet, The P2Y12 receptor induces platelet aggregation through weak activation of the αIIbβ3 integrin – a phosphoinositide 3‐kinase‐dependent mechanism FEBS Letters. ,vol. 505, pp. 281- 290 ,(2001) , 10.1016/S0014-5793(01)02824-1
A. SUGIDACHI, T. OGAWA, A. KURIHARA, K. HAGIHARA, J.A. JAKUBOWSKI, M. HASHIMOTO, Y. NIITSU, F. ASAI, The greater in vivo antiplatelet effects of prasugrel as compared to clopidogrel reflect more efficient generation of its active metabolite with similar antiplatelet activity to that of clopidogrel's active metabolite. Journal of Thrombosis and Haemostasis. ,vol. 5, pp. 1545- 1551 ,(2007) , 10.1111/J.1538-7836.2007.02598.X
John T. Brandt, Christopher D. Payne, Stephen D. Wiviott, Govinda Weerakkody, Nagy A. Farid, David S. Small, Joseph A. Jakubowski, Hideo Naganuma, Kenneth J. Winters, A comparison of prasugrel and clopidogrel loading doses on platelet function: magnitude of platelet inhibition is related to active metabolite formation. American Heart Journal. ,vol. 153, ,(2007) , 10.1016/J.AHJ.2006.10.010
Yoichi Niitsu, Joseph A Jakubowski, Atsuhiro Sugidachi, Fumitoshi Asai, Pharmacology of CS-747 (prasugrel, LY640315), a novel, potent antiplatelet agent with in vivo P2Y12 receptor antagonist activity. Seminars in Thrombosis and Hemostasis. ,vol. 31, pp. 184- 194 ,(2005) , 10.1055/S-2005-869524