The prevalence of BRCA1 and BRCA2 mutations among young Mexican women with triple-negative breast cancer.
作者： C. Villarreal-Garza , J. N. Weitzel , M. Llacuachaqui , E. Sifuentes , M. C. Magallanes-Hoyos
DOI: 10.1007/S10549-015-3312-8
关键词:
摘要: Various guidelines recommend that women with triple-negative breast cancer should be tested for BRCA1 mutations, but the prevalence of mutations may vary ethnic group and geographic region, optimal cutoff age testing has not been established. We estimated frequencies BRCA2 (BRCA) among 190 cancer, unselected family history, diagnosed at 50 or less a single hospital in Mexico City. Patients were screened 115 recurrent BRCA which have reported previously Hispanic origin, including common large rearrangement Mexican founder mutation (BRCA1 ex9-12del). A was detected 44 patients (23 %). Forty-three found one BRCA2. Seven different accounted 39 (89 % total mutations). The ex9-12del) 18 times 41 all detected. There is high young Mexico. Women BRCA1.
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