Coenzyme Q10 with multiple vitamins is generally ineffective in treatment of mitochondrial disease

摘要: We followed 16 patients with a variety of mitochondrial diseases over one to four periods treatment (2 months each) coenzyme Q 10 plus vitamins K 3 and C, riboflavin, thiamine, niacin, using independent measures oxidative metabolism assess efficacy. There were large ( concentrations treatment, but no measure showed significant improvement for the group, nor did any individual patient show significant, reproducible, objective clinical improvement. The results suggest that vitamin therapy does not significantly improve in disease general. Any benefit may follow from short-term administration appears slight.