Systemic Immunosuppressants in the Treatment of Pruritus

摘要: Pruritus is a sensation that, if sufficiently strong, will provoke scratching or the desire to scratch.1 It perhaps most common dermatological symptom associated not only with numerous skin diseases but also extracutaneous disorders in absence of any kind objective illness. Itch propagated by complex mechanisms located both peripherally and within central nervous system. The concern for patient physician alike cure chronic itch. Traditional systemic treatments have limited efficacy new options are emerging slowly. New insights recently been obtained understanding itch transmission physiology, such progress can contribute further development more effective therapies. In fact, therapeutic strategies rely mainly on deep pruritus pathophysiology. Definitions different types described and, although no perfect classification system exists, one accepted clinical proposed Bernhard.2 He classifies into six categories: (1) dermatologic (arising from as psoriasis, eczema, winter itch, scabies, urticaria; (2) internal primary cholestatic liver disease, renal failure, Hodgkin’s polycythemia vera, some multifactorial [e.g., metabolic] situations); (3) neurogenic/neuropathic peripheral system, brain tumors, multiple sclerosis, neuropathy, nerve compression irritation notalgia paresthetica brachioradial pruritus]); (4) psychogenic; (5) mixed; (6) others.