Interindividual Heterogeneity in the Hypoxic Regulation of VEGF Significance for the Development of the Coronary Artery Collateral Circulation

摘要: Background—The coronary artery collateral circulation may be beneficial in protecting against myocardial ischemia and necrosis. However, there is a tremendous interindividual variability the degree of new formation patients with disease. The basis for this heterogeneity not understood. In study we test hypothesis that failure to generate vessels associated appropriately induce hypoxia or angiogenic factor, vascular endothelial growth factor (VEGF). Methods Results—We correlated VEGF response monocytes harvested from disease presence collaterals visualized during routine angiography. We found was highly significant difference hypoxic induction no compared some (mean fold 1.9±0.2 versus 3.2±0.3, P<0.0001). After subjecting data ...