Complement modulation of T cell immune responses during homeostasis and disease

摘要: The complement system is an ancient and critical effector mechanism of the innate immune as it senses, kills, clears infectious and/or dangerous particles alerts to presence infection danger. Interestingly, increasing number reports have demonstrated a clear role for in adaptive well. Of note, recent studies identified previously unknown roles proteins, receptors, regulators T cell function. Here, we will review data demonstrating influence proteins C1q, C3b/iC3b, C3a (and C3aR), C5a C5aR) DAF (CD55) CD46 (MCP) on function during homeostasis disease. Although new concepts are beginning emerge field regulation function, future experiments should focus whether interacting directly with or having indirect effect via APCs, cytokine milieu, downstream activation products. Importantly, identification pivotal molecular pathways human systems be beneficial translation derived from model therapeutic targeting treatment disorders.