How the immune system works

摘要: Acknowledgments, vii How to Use This Book, viii book is neither a comprehensive text nor an exam-review tool. It overview of the immune system, designed give anyone who learning immunology feel for how system fits together. Lecture 1 An Overview, The team effort, involving many different players work together provide powerful defense against invaders. Focusing in on one player at time makes it hard understand game. Here we view action from grandstands get wide-angle picture what all about. 2 Innate Immune System, 13 innate hard-wired that has evolved over millions years recognize pathogens commonly infect humans. provides rapid and response everyday 3 B Cells Antibodies, 27 cells antibodies they produce are part adaptive system. evolves during our own lifetime protect us invaders we, personally, have never encountered before. 4 Magic Antigen Presentation, 42 T cells, another weapon only which properly presented by specialized antigen presenting cells. feature keeps these important focused particular attackers able defend against. 5 Cell Activation, 55 Before can spring into action, must be activated. requirement helps insure useful weapons will mobilized. 6 Work, 63 Once been activated, helper orchestrate response, killer destroy infected 7 Secondary Lymphoid Organs Lymphocyte Trafficking, 72 lymphocytes travel through secondary lymphoid organs looking intruders activated organs, dispatched areas body where most useful. 8 Restraining 84 restrained lest become overexuberant. In addition, once invader defeated, reset prepare future attacks. 9 Self Tolerance MHC Restriction, 88 trained focus appropriately invaders, learn not attack bodies. 10 Immunological Memory, 98 remembers attacking humans years. contrast, remember lifetime. Memory respond more quickly effectively subsequent same invader. 11 Intestinal 103 human intestines home trillions bacteria, viruses, fungi, parasites. deals with potentially dangerous intestinal residents, frequently invade tissues surrounding intestines, hot topic immunology. 12 Vaccines, 110 Vaccines safely mimic so primed ready challenge System Gone Wrong, 116 generally does good job defending without causing lot collateral damage. Sometimes, however, mistakes made. 14 Immunodeficiency, 126 Serious disease may result when operate full strength. Humans AIDS virus profoundly impaired systems. 15 Cancer 131 very cancer. Indeed, there built-in conflict between need minimize chance its bodies, wannabe cancer Glossary, 139 definitions some terms immunologists use but normal people wouldn t. List Acronyms Abbreviations, 142 Immunologists big acronyms abbreviations, I ve made list you refer. Index, 143