The prognostic and diagnostic markers of invasive candidiasis in patients during chemotherapy.
作者： Beata Gabczynska , Maria Koziol-Montewka , Elzbieta Staroslawska , Agnieszka Magrys
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摘要: The aim of the work was early detection Candida spp. in clinical samples patients with carcinoma ovariorum undergoing chemotherapy by comparing three indicators candidiasis: presence mannan and yeast DNA bloodstream colonization mucosal membranes species as a prognostic marker deep candidiasis. Thirty-one women ovariorum, during without symptoms fungal infections, were examined twice over six-day period. C. albicans dominant organism isolated from membranes. Two serum positive for on first day examination. All these previously colonized mucous Four last Three infection detected 4 out 12 combination PCR mannan-detecting methods. Colonization increases risk antigen are fast reliable methods bloodstream. For at risk, must be tested least two independent K e y w o r d s: cancer, candidiasis,
参考文章(18)
M Rossier, P Charache, W G Merz, T G Buchman, Detection of surgical pathogens by in vitro DNA amplification. Part I. Rapid identification of Candida albicans by in vitro amplification of a fungus-specific gene. Surgery. ,vol. 108, pp. 338- 347 ,(1990)
Jong Hee Shin, Frederick S. Nolte, Brian P. Holloway, Christine J. Morrison, Rapid identification of up to three Candida species in a single reaction tube by a 5' exonuclease assay using fluorescent DNA probes. Journal of Clinical Microbiology. ,vol. 37, pp. 165- 170 ,(1999) , 10.1128/JCM.37.1.165-170.1999
D L Yamamura, S Ioannou, L E Nicolle, C Rotstein, Candidemia at selected Canadian sites: results from the Fungal Disease Registry, 1992-1994 Canadian Medical Association Journal. ,vol. 160, pp. 493- 499 ,(1999)
M. Flahaut, D. Sanglard, M. Monod, J. Bille, M. Rossier, Rapid detection of Candida albicans in clinical samples by DNA amplification of common regions from C. albicans-secreted aspartic proteinase genes. Journal of Clinical Microbiology. ,vol. 36, pp. 395- 401 ,(1998) , 10.1128/JCM.36.2.395-401.1998
A R Holmes, R D Cannon, M G Shepherd, H F Jenkinson, Detection of Candida albicans and other yeasts in blood by PCR. Journal of Clinical Microbiology. ,vol. 32, pp. 228- 231 ,(1994) , 10.1128/JCM.32.1.228-231.1994
Malcolm D Richardson, Maarit H Kokki, New perspectives in the diagnosis of systemic fungal infections Annals of Medicine. ,vol. 31, pp. 327- 335 ,(1999) , 10.3109/07853899908995899
M.A. Pfaller, Epidemiology of candidiasis Journal of Hospital Infection. ,vol. 30, pp. 329- 338 ,(1995) , 10.1016/0195-6701(95)90036-5
Albert Balows, Manual of Clinical Microbiology, 7th ed. Diagnostic Microbiology and Infectious Disease. ,vol. 36, pp. 143- ,(2000) , 10.1016/S0732-8893(99)00102-9
R. Rüchel, Clinical presentation of invasiveCandidamycoses Mycoses. ,vol. 40, pp. 17- 20 ,(1997) , 10.1111/J.1439-0507.1997.TB00558.X
S. Kwok, R. Higuchi, Avoiding false positives with PCR Nature. ,vol. 339, pp. 237- 238 ,(1989) , 10.1038/339237A0